Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Werke, and: Vol. 1, Schriften zum Spinozastreit (1998), and: Vol. 2, Schriften zum transzendentalen Idealismus (2004), and: Vol. 3, Schriften zum Streit um die göttlichen Dinge und ihre Offenbarung (2000)Rolf AhlersFriedrich Heinrich Jacobi. Werke. Edited by Klaus Hammacher and Walter Jaeschke. Vol. 1, Schriften zum Spinozastreit ( 1998). Vol. 2, Schriften zum transzendentalen Idealismus ( 2004). Vol. 3, Schriften zum Streit um die göttlichen Dinge und ihre Offenbarung (...) ( 2000). Pp. x + 640. Cloth, € 168,00 (Vol. 1). Pp. vii + 823. Cloth, € 264,00 (Vol. 2). Pp. vi + 262. Cloth, € 78,00 (Vol. 3). Hamburg: Felix Meiner Verlag, 1998, 2000, 2004.The new critical Jacobi Werke Ausgabe (JWA), accompanied by four volumes of the still incomplete Briefwechsel (in progress at Frommann-Holzboog Publishers since 1981), is a masterpiece of research on Jacobi, early German Idealism and early Romanticism. Now [End Page 491] available are Volumes I, II and III. Volume I (1998) carries the title Schriften zum Spinozastreit and contains Jacobi's Spinozabriefe in the three editions of 1785, 1789, and 1819, Wider Mendelssohns Beschuldigungen of 1786, and the Vorbericht (Preface) of the third edition of the Spinozabriefe of 1819. The running text of all writings contains all editions, variant readings clearly identifiable with page references in the margins, subscripted to identify the various editions. This method enables the identification of various disputes which Jacobi provoked and in which his writings played a role. The Anhang, appendix, to all texts contains a) a list of abbreviations, and b) the editorial principles used and also a description of the circumstances leading to the writing of the texts. But the bulk of the Anhang of each volume is c) the "Kommentar," the commentary. It provides the key to the highly nuanced and, without guidance, the often cryptic allusions and references of Jacobi's texts. This commentary (separately bound in Volumes I and II) really brings Jacobi's work to life. The end of the Anhang contains d) a bibliography of all works mentioned not only by Jacobi himself but also emerging in the literary debate unlocked by the commentary, as well as e) an extensive index of names. Volume II (2004) is Schriften zur Transzendentalphilosophie, and contains David Hume of 1787, the Sendschreiben an Fichte, Ueberflüssiges Taschenbuch, both of 1799, and other essays such as Three Letters to Köppen of 1803. Volume III (2000) is Schriften zum Streit um die Göttlichen Dinge and contains mainly the famous essay Von den Göttlichen Dingen of 1811 plus three other writings. This book deals with the controversy between Schelling and Jacobi while both were at Munich. Other major works of Jacobi, such as the novel Allwill, are to follow in later volumes.This critical edition of Fr. H. Jacobi (1743–1819) definitively revises the standard interpretation of the man and his work. The standard interpretation (advocated by such figures as Fr. Schlegel, Moses Mendelssohn, and H. Heine) views his thought as promoting irrationalism, specifically a religious irrationalism of faith, taking form in "personalism." Heine spoke of Jacobi as a "whiney old biddy." Fr. Schlegel characterized Jacobi's salto mortale as the "leap into the arms of divine mercy," promoting an irrational "philosophical non-philosophy" (KFSA XVIII 13, Nr. 101). Schlegel criticized Jacobi at the very end of in his Woldemar Review of 1796 thus: "So (Jacobi's) Woldemar is really an invitation to meet God..., and (his) theological masterpiece ends, as do all moral excesses, with a salto mortale... into the abyss of divine mercy" (Früher Idealismus und Frühromantik PlS I.1, ed. W. Jaeschke [Hbg: Meiner, 1995], 270). Carl Philipp Moritz credited Jacobi with "fanaticism and superstition."In contrast, Jacobi himself was quite critical of this characterization of his thought, especially in the Sendschreiben of 1799, and earlier in his Briefe. Jacobi already in 1786 thought it was "outrageous" for Mendelssohn to suggest he surrenders a philosophy of reason in favor of the Christian faith, or worse. He addresses this problem, which is still today the dominant view of the "irrationality" of his "leap," with admirable clarity in his letter to Neeb of May 30, 1817: "I do not at all advocate a head-first... (shrink)

Existing research shows consistently high levels of concern among people in the UK over the scale of immigration and its impact on jobs, wages and services. At the same time, that same body of research does not provide much in the way of detail about the nature of these concerns. This is partly because much of the data is from opinion polls which say little about the priorities and perspectives that underlie the aggregate numbers. Moreover, very little research has been (...) carried out on what new immigration policies the British public would like to see once the UK leaves the EU and free movement ends. Our research for this report aims to fill these gaps by providing evidence about how people use and understand information about economic impacts of immigration, and what they might wish to see from new, post-Brexit, policies. (shrink)

Name der Zeitschrift: Jahrbuch für Wissenschaft und Ethik Jahrgang: 22 Heft: 1 Seiten: 65-86.

Many adoptees face a number of challenges relating to separation from biological parents during the adoption process, including issues concerning identity, intimacy, attachment, and trust, as well as language and other cultural challenges. One common health challenge faced by adoptees involves lack of access to genetic-relative family health history. Lack of GRFHx represents a disadvantage due to a reduced capacity to identify diseases and recommend appropriate screening for conditions for which the adopted person may be at increased risk. In this (...) article, we draw out common features of traditionally understood “health disparities” in order to identify analogous features in the context of adoptees’ lack of GRFHx. (shrink)

Open discourses and the free formation of opinions through unfettered information flows and communicated diversity of opinion are unthinkable without independent media and essential prerequisites for a functioning democracy. Notwithstanding the importance of the linkage between media and democracy, there is no harmonized framework addressing this issue. By adopting a legal perspective, this study shall outline existing and emerging regulations, with a particular focus on broadcast, print, and online media Two regulatory tiers are distinguished: At the international level, the establishment (...) of aWorld Information Order as well as the human rights perspective intrinsic to the subject matter will be addressed. At the national level, legal approaches to particular tensions accompanying state regulation of the media will be examined. (shrink)

Ethics in the West too often equates morality with universal moral principles, thus imposing lifestyles and moral criteria that do not respect differences and local histories. Even Christianity proposes ethics that is based on eternal, absolute and universal truths or principles, independent of sociocultural and historical contexts. The problem is that these universal moral laws become a means of social control to exclude those who are different: non-Christian religions, nonwhite races, non-Western cultures, and poor and marginalized social classes everywhere. To (...) these can be added minorities marginalized because of sexual orientation, physical handicaps, and women of all sectors and cultures. Another kind of ethics is urgent. For these reasons, Christians in Latin America and other parts are seeking innovative ways of envisioning ethics from their marginalized and discriminated social locations in order to find another possible ethics, an ethics that is not universal and not based on eternal truths or principles, but rather is contextual and historical and that takes into account real-life realities. Only an ethics that does this will be liberative. Important steps toward this other possible ethics have been taken by the theology of liberation by developing a contextual and intercultural morality. (shrink)

Cosmic Christology, including deep incarnation, provides an ethical-theological framework for confronting environmental crisis. It criticizes ‘history’ as arrogantly anthropocentric and proposes a paradigm shift from Christ the Saviour of history to the Christ of the cosmos. Whereas I recognize these strengths for protecting nature, I argue that in its universal pretension Christ too often becomes an abstract reality and loses material grounding for social justice. In its eagerness to supplant the Christ the Saviour of history, cosmic Christology risks stripping humanity (...) from those deemed ‘non-persons’ and inadvertently reinforces the status of the oppressed as subalterns. Likewise, by de-legitimizing history, and by putting exploited nature and the oppressed as equivalents, struggles by subalterns for recognition and justice are diminished. To avoid this, I argue that the salvation of nature passes through the salvation of history. Only the Christ the Saviour of history can be the cosmic Christ. (shrink)

Pursuant to the Doctrine of Consumer Sovereignty, we believe that tobacco companies should be compelled to disclose their ingredients so that the public health community can make more informed recommendations in order to protect consumer autonomy and sovereignty. However, a recent decision by the First Circuit precludes such a disclosure since it would be unduly burdensome to the industry, while granting only minimal gains to the public. We argue that many of the Court’s key claims rest on a misunderstanding of (...) the science and chemistry of tobacco products. In our view, a mandatory disclosure of ingredients would more effectively protect the public interest, whilst posing minimal burdens on the tobacco industry. (shrink)

This article combines findings from cognitive psychology on the role of processing fluency in truth judgments with epistemological theory on justification of belief. We first review evidence that repeated exposure to a statement increases the subjective ease with which that statement is processed. This increased processing fluency, in turn, increases the probability that the statement is judged to be true. The basic question discussed here is whether the use of processing fluency as a cue to truth is epistemically justified. In (...) the present analysis, based on Bayes’ Theorem, we adopt the reliable-process account of justification presented by Goldman (1986) and show that fluency is a reliable cue to truth, under the assumption that the majority of statements one has been exposed to are true. In the final section, we broaden the scope of this analysis and discuss how processing fluency as a potentially universal cue to judged truth may contribute to cultural differences in commonsense beliefs. (shrink)

This paper argues that it will be important for new genomic technologies to recognize the limits of traditional approaches to informed consent, so that other-regarding implications of genomic information can be properly contextualized and individual rights respected. Respect for individual autonomy will increasingly require dynamic consideration of the interrelated dimensions of individual and broader community interests, so that the interests of one do not undermine fundamental interests of the other. In this, protection of individual rights will be a complex interplay (...) between individual and community concerns. (shrink)

P3 is the most prominent of the electrical potentials of the human electroencephalogram that are sensitive to psychological variables. According to the most influential current hypothesis about its psychological significance [E. Donchin's], the “context updating” hypothesis, P3 reflects the updating of working memory. This hypothesis cannot account for relevant portions of the available evidence and it entails some basic contradictions. A more general formulation of this hypothesis is that P3 reflects the updating of expectancies. This version implies that P3-evoking stimuli (...) are initially unexpected but later become expected. This contradiction cannot be resolved within this formulation. The alternative “context closure” hypothesis retains the concept of “strategic information processing” emphasized by the context updating hypothesis. P3s are evoked by events that are awaited when subjects deal with repetitive, highly structured tasks; P3s arise from subjects' combining successive stimuli into larger units. The tasks in which P3s are elicited can accordingly be classified in terms of their respective formal sequences of stimuli. P3 may be a physiological indicator of excess activation being released from perceptual control areas. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

Depression is a disorder of impaired emotion regulation. Consequently, examining individual differences in the habitual use of emotion-regulation strategies has considerable potential to inform models of this debilitating disorder. The aim of the current study was to identify cognitive processes that may be associated with the use of emotion-regulation strategies and to elucidate their relation to depression. Depression has been found to be associated with difficulties in cognitive control and, more specifically, with difficulties inhibiting the processing of negative material. We (...) used a negative affective priming task to assess the relations among inhibition and individual differences in the habitual use of rumination, reappraisal, and expressive suppression in clinically depressed, formerly depressed, and never-depressed participants. We found that depressed participants exhibited the predicted lack of inhibition when processing negative material. Moreover, within the group of depressed participants, reduced inhibition of negative material was associated with greater rumination. Across the entire sample, reduced inhibition of negative material was related to less use of reappraisal and more use of expressive suppression. Finally, within the formerly depressed group, less use of reappraisal, more use of rumination, and greater expressive suppression were related to higher levels of depressive symptoms. These findings suggest that individual differences in the use of emotion-regulation strategies play an important role in depression, and that deficits in cognitive control are related to the use of maladaptive emotion-regulation strategies in this disorder. (shrink)

Is helping those whose subsistence needs are not meet a matter of charity or an obligation? What role should ordinary citizens of developed nations play? In a globalized world, the causes, connections, and responsibilities become complicated. Agriculture subsidies that keep food prices low for many in relatively rich countries may, for example, negatively impact poor farmers in developing countries. Students in Ethics/Philosophy 352 report on their project examining whether, and to what extent, a true obligation to aid exists.

My aim here is to make sense of Plato's account of desire in the middle dialogues. To do that I need to unify or reconcile what are at first sight two quite different accounts: the doctrine of eros in the Symposium and the tripartite theory of motivation in the Republic. It may be that the two theories are after all irreconcilable, that Plato simply changed his mind on the nature of human desire after writing the Symposium and before composing the (...) Republic. But that conclusion can be justified only if attempts to reconcile the two theories end in failure. The attempt must be made first. (shrink)

In the past two decades, reinforcement learning has become a popular framework for understanding brain function. A key component of RL models, prediction error, has been associated with neural signals throughout the brain, including subcortical nuclei, primary sensory cortices, and prefrontal cortex. Depending on the location in which activity is observed, the functional interpretation of prediction error may change: Prediction errors may reflect a discrepancy in the anticipated and actual value of reward, a signal indicating the salience or novelty of (...) a stimulus, and many other interpretations. Anterior cingulate cortex has long been recognized as a region involved in processing behavioral error, and recent computational models of the region have expanded this interpretation to include a more general role for the region in predicting likely events, broadly construed, and signaling deviations between expected and observed events. Ongoing modeling work investigating the interaction between ACC and additional regions involved in cognitive control suggests an even broader role for cingulate in computing a hierarchically structured surprise signal critical for learning models of the environment. The result is a predictive coding model of the frontal lobes, suggesting that predictive coding may be a unifying computational principle across the neocortex. (shrink)

The multifunctional zinc‐finger protein CCCTC‐binding factor (CTCF) is a very strong candidate for the role of coordinating the expression level of coding sequences with their three‐dimensional position in the nucleus, apparently responding to a “code” in the DNA itself. Dynamic interactions between chromatin fibers in the context of nuclear architecture have been implicated in various aspects of genome functions. However, the molecular basis of these interactions still remains elusive and is a subject of intense debate. Here we discuss the nature (...) of CTCF‐DNA interactions, the CTCF‐binding specificity to its binding sites and the relationship between CTCF and chromatin, and we examine data linking CTCF with gene regulation in the three‐dimensional nuclear space. We discuss why these features render CTCF a very strong candidate for the role and propose a unifying model, the “CTCF code,” explaining the mechanistic basis of how the information encrypted in DNA may be interpreted by CTCF into diverse nuclear functions. (shrink)

High figure-ground contrast usually results in more positive evaluations of visual stimuli. This may either reflect that high figure-ground contrast per se is a desirable attribute or that this attribute facilitates fluent processing. In the latter case, the influence of high figure-ground contrast should be most pronounced under short exposure times, that is, under conditions where the facilitative influence on perceptual fluency is most pronounced. Supporting this hypothesis, ratings of the prettiness of visual stimuli increased with figure-ground contrast under short (...) exposure times (.3, 1, and 3 seconds, respectively). This positive influence of figure-ground contrast was eliminated under an exposure time of 10 seconds. We conclude that stimuli with high figure-ground contrast are more appealing because they are easier to process, not because high figure-ground contrast per se is a desirable attribute. We discuss this finding in the context of William James? notion that the fringe of consciousness includes vague contextual feelings at the periphery of the focus of attention and suggest that perceptual fluency is one of these feelings. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

Emotion experience reflects some of the outcomes of the mostly nonconscious processes that compose emotions. In my view, the major processes are appraisal, affect, action readiness, and autonomic arousal. The phenomenology of emotion experience varies according to mode of consciousness (nonreflective or reflective consciousness), and to direction and mode of attention. As a result, emotion experience may be either ineffable or articulate with respect to any or all of the underlying processes. In addition, emotion experience reflects the degree to which (...) the emotion processes control perception, thought, action and bodily arousal. (shrink)

The claim that argumentation has no proper role in either philosophy or education, and especially not in philosophical education, flies in the face of both conventional wisdom and traditional pedagogy. There is, however, something to be said for it because it is really only provocative against a certain philosophical backdrop. Our understanding of the concept "argument" is both reflected by and molded by the specific metaphor that argument-is-war, something with winners and losers, offensive and defensive moments, and an essentially adversarial (...) structure. Such arguments may be suitable for teaching a philosophy, but not for teaching philosophy. Surely, education and philosophy do not need to be conceived as having an adversarial essence-if indeed they are thought to have any essence at all. Accordingly, philosophy and education need more pragmatic goals than even Pierce's idealized notion of truth as the end of inquiry, e.g., the simple furtherance of inquiry. For this, new metaphors for framing and understanding the concept of argumentation are needed, and some suggestions in that direction will be considered. (shrink)

Human adults incline toward moral objectivism but may approach things more relativistically if different cultures are involved. In this study, 4-, 6-, and 9-year-old children (N = 136) witnessed two parties who disagreed about moral matters: a normative judge (e.g., judging that it is wrong to do X) and an antinormative judge (e.g., judging that it is okay to do X). We assessed children’s metaethical judgment, that is, whether they judged that only one party (objectivism) or both parties (relativism) could (...) be right. We found that 9-year-olds, but not younger children, were more likely to judge that both parties could be right when a normative ingroup judge disagreed with an antinormative extraterrestrial judge (with different preferences and background) than when the antinormative judge was another ingroup individual. This effect was not found in a comparison case where parties disagreed about the possibility of different physical laws. These findings suggest that although young children often exhibit moral objectivism, by early school age they begin to temper their objectivism with culturally relative metaethical judgments. (shrink)

Combatting chronic, lifestyle-related disease has become a healthcare priority in the developed world. The role personal responsibility should play in healthcare provision has growing pertinence given the growing significance of individual lifestyle choices for health. Media reporting focussing on the ‘bad behaviour’ of individuals suffering lifestyle-related disease, and policies aimed at encouraging ‘responsibilisation’ in healthcare highlight the importance of understanding the scope of responsibility ascriptions in this context. Research into the social determinants of health and psychological mechanisms of health behaviour (...) could undermine some commonly held and tacit assumptions about the moral responsibility of agents for the sorts of lifestyles they adopt. I use Philip Petit's conception of freedom as ‘fitness to be held responsible’ to consider the significance of some of this evidence for assessing the moral responsibility of agents. I propose that, in some cases, factors outside the agent's control may influence behaviour in such a way as to undermine her freedom along the three dimensions described by Pettit: freedom of action; a sense of identification with one's actions; and whether one's social position renders one vulnerable to pressure from more powerful others. (shrink)